Aromatase Inhibitor | Estrogen Suppression for Hormone Management
Letrozole is a potent third-generation aromatase inhibitor (AI) used to suppress estrogen production by inhibiting the aromatase enzyme. At a 2.5mg strength, Letrozole is typically reserved for cases requiring aggressive estrogen control, such as estrogen rebound post-cycle, or to manage gynecomastia symptoms that don’t respond to milder AIs like Arimidex.
While originally developed for clinical use in estrogen-sensitive conditions, it is commonly used off-label in performance enhancement and post-cycle therapy (PCT) protocols.
Aromatase Inhibitor | Estrogen Suppression for Hormone Management
Overview:
Letrozole is a potent third-generation aromatase inhibitor (AI) used to suppress estrogen production by inhibiting the aromatase enzyme. At a 2.5mg strength, Letrozole is typically reserved for cases requiring aggressive estrogen control, such as estrogen rebound post-cycle, or to manage gynecomastia symptoms that don’t respond to milder AIs like Arimidex.
While originally developed for clinical use in estrogen-sensitive conditions, it is commonly used off-label in performance enhancement and post-cycle therapy (PCT) protocols.
Product Details:
• Dosage: 2.5mg per tablet
• Quantity: 100 tablets per bottle
• Form: Oral tablet, may be split for lower doses
• Use Case: Estrogen control during or after anabolic cycles, or in advanced TRT support
Key Benefits:
• Provides strong suppression of estrogen (estradiol)
• May help manage or reverse gynecomastia-related symptoms
• Used in post-cycle estrogen rebound prevention
• Offers a solution when milder AIs (e.g., Anastrozole) are insufficient
Common Protocols:
• Mild Estrogen Control: 0.25–0.5mg every other day
• Aggressive Protocols / Gyno Reversal: 1.25–2.5mg per day short-term
• Tapering Required: Avoid abrupt cessation to prevent estrogen rebound
• Always dose based on lab results to prevent over-suppression
Monitoring & Considerations:
• Monitor: Estradiol (sensitive assay), libido, joint comfort, and mood
• Possible side effects if overdosed: Dry joints, fatigue, low libido, mood swings, cognitive fog
• Stronger than Arimidex or Aromasin — use only when clinically indicated
• Best used under medical or qualified supervision
Note: Letrozole is a powerful tool for advanced estrogen management, best suited for experienced users or those with specific needs beyond general TRT support. Start low, monitor labs, and adjust accordingly.
